Charts, Diagrams and Timelines

The Longitude Problem

A ship's latitude — how far north or south it is — can be found from the height of the sun at noon. Sailors could do that for centuries. Longitude, how far east or west, was the problem. It has no natural marker. The solution was known in principle: compare the time on board with the time at a fixed place. The Earth turns fifteen degrees an hour, so every hour of difference is fifteen degrees of longitude. That required a clock that stayed accurate on a rolling, salty, temperature-swinging ship. No such clock existed. John Harrison, a carpenter, spent forty-three years building four. The fourth, finished in 1759, was the size of a large pocket watch and lost five seconds in eighty-one days at sea.

How Penicillin Was Found

In 1928 Alexander Fleming went on holiday and left a stack of dishes on a bench. Each held a colony of bacteria. When he came back, one dish had a spot of mould on it. Around the mould was a clear ring where the bacteria had died. Fleming realised the mould was producing something that killed bacteria. He named it penicillin and published a paper. Almost nobody noticed. Ten years later, Howard Florey and Ernst Chain read that paper and tried to make penicillin in quantity. That turned out to be the hard part: it took two thousand litres of mould fluid to treat one patient. By 1944 the problem had been solved and penicillin was reaching soldiers in the field.